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Filtered Search Results
Medchemexpress LLC GW6471 | 880635-03-0 | C35H36F3N3O4 | 100 MG
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GW6471 is a potent PPARα antagonist that inhibits GW409544-induced activation of PPARα with an IC50 of 0.24 μM. It significantly inhibits cell viability in Caki-1 and 786-O renal cell carcinoma cell lines in vitro. In vivo studies demonstrate its antitumor activity, showing decreased tumor growth and c-Myc levels in xenograft mouse models without observed toxicity.
- Potent PPARα antagonist
- Inhibits cell viability in renal cell carcinoma cell lines
- Demonstrates antitumor activity in vivo
- No toxicity observed at effective doses in animal studies
- Cited in numerous publications, including Nat Metab, Cell Metab, and Immunity
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Medchemexpress LLC Prexasertib (dimesylate) | 1234015-58-7 | 98.9% | 557.60 | 50 MG
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Prexasertib (dimesylate) | 1234015-58-7 | 98.9% | 557.60 | 50 MG
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Medchemexpress LLC S-verapamil hydrochloride | 36622-28-3 | MFCD11045898 | 98.3% | 491.06 | C27H39ClN2O4 | 5 MG
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(S)-Verapamil hydrochloride is the S-enantiomer of the calcium channel blocker verapamil, provided as a hydrochloride salt for research use. It functions as a P-glycoprotein and MRP1 inhibitor and is employed in in vitro pharmacology and drug transport studies, including investigations of multidrug resistance.
- Single S-enantiomer for stereospecific pharmacology.
- Hydrochloride salt form for improved solubility and handling.
- Reported to inhibit P-gp and MRP1-mediated transport.
- Suitable for in vitro assays and pharmacological studies.
- Available as solid and DMSO solution formats.
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Medchemexpress LLC Prexasertib (dimesylate) | 1234015-58-7 | 98.9% | 557.60 | 5 MG
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Prexasertib dimesylate is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. It also inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). This compound induces double-stranded DNA breakage and replication catastrophe, leading to apoptosis, and demonstrates potent anti-tumor activity.
- Selective, ATP-competitive CHK1 inhibitor
- Inhibits CHK1 (Ki 0.9 nM, IC50 <1 nM), CHK2, and RSK1
- Induces double-stranded DNA breakage and replication catastrophe
- Leads to apoptosis and potent anti-tumor activity
- Inhibits MELK, SIK, BRSK2, and ARK5
- Requires CDC25A and CDK2 for DNA damage
- Causes DNA damage during S-phase
- Inhibits CHK1 and CHK2 autophosphorylation
- Induces cell-cycle shift with H2AX phosphorylation
- Triggers chromosomal fragmentation and replication stress
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Medchemexpress LLC BAY-985 50 mg
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BAY-985 50MG
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Medchemexpress LLC Rocaglamide | 84573-16-0 | 505.56 | 50 MG
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Rocaglamide is isolated from the genus Aglaia and can be used for coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB activation in T-cells and a selective heat shock factor 1 (HSF1) activation inhibitor with an IC50 of ~50 nM. Rocaglamide also inhibits the function of the translation initiation factor eIF4A and exhibits anticancer properties in leukemia.
- Isolated from the genus Aglaia.
- Can be used for coughs, injuries, asthma, and inflammatory skin diseases.
- Potent inhibitor of NF-κB activation in T-cells.
- Potent and selective heat shock factor 1 (HSF1) activation inhibitor.
- Inhibits the function of the translation initiation factor eIF4A.
- Has anticancer properties in leukemia.
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eMolecules 21498-08-8 | Medchem Express | Lofexidine (hydrochloride) | 50mg | 482204536 | HY-B1052 | MFCD00917022 | 295.59 | C11H13Cl3N2O
Ambeed | 2-((25-Dioxopyrrolidin-1-yl)oxy)-13-dimethyl-3456-tetrahydropyrimidin-1-ium hexafluorophosphate(V) | 1g | 682929939 | A216375 | 443305-33-7 | MFCD11615809 | 371.220 | C10H16F6N3O3P
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Medchemexpress LLC HY-103533 5mg Medchemexpress, Gabazine CAS:104104-50-9 Purity:>98%
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Medchemexpress, HY-103533 5mg Gabazine CAS:104104-50-9 Gabazine is a selective and competitive antagonist of GABAA receptor, with an IC50 of ~0.2 μM for GABA receptor. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-102014 5mg Medchemexpress, RN-18 CAS:431980-38-0 Purity:>98%
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Medchemexpress, HY-102014 5mg RN-18 CAS:431980-38-0 RN-18 is a HIV-1 viral infectivity factor (HIV-1 Vif) inhibitor with an IC50 of 6 μM in nonpermissive H9 cells. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC GT 949 25mg | 460330-27-2 | 25 MG
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GT 949 is a selective positive allosteric modulator of the excitatory amino acid transporter 2 (EAAT2) that enhances glutamate transport with high potency (EC50 = 0.26 nM). It is supplied as a research reagent and is stable under recommended storage conditions.
- Selective EAAT2 positive allosteric modulator with EC50 ≈ 0.26 nM.
- Enhances glutamate transport without affecting EAAT1 or EAAT3.
- High purity suitable for research applications.
- Molecular formula C30H37N7O2; molecular weight 527.66 g·mol⁻1.
- Store powder at -20°C; store in solution at -80°C for long-term storage.
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Medchemexpress LLC Rigosertib sodium | 592542-60-4 | 99.6% | 10MG
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Rigosertib sodium | 592542-60-4 | 99.6% | 10MG
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Enzo Life Sciences Aristolochic acid. sodium salt (50mg). CAS: 10190-99-5
Water soluble form of aristolochic acid. Purity: ≥97%. Solubility: Soluble in water. Long Term Storage: Ambient.
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Medchemexpress LLC HY-B0161A 50mg Medchemexpress, Duloxetine (hydrochloride) CAS:136434-34-9 Purity:>98%
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Medchemexpress, HY-B0161A 50mg Duloxetine (hydrochloride) CAS:136434-34-9 Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Aobchem 4-Phenoxy-3-(trifluoromethyl)aniline | ≥95% | CAS 267416-81-9 | C13H10F3NO | 1g
4-Phenoxy-3-(trifluoromethyl)aniline | ≥95% | CAS 267416-81-9 | C13H10F3NO | 1g
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Aobchem 4-Phenoxy-3-(trifluoromethyl)aniline | ≥95% | CAS 267416-81-9 | C13H10F3NO | 5g
4-Phenoxy-3-(trifluoromethyl)aniline | ≥95% | CAS 267416-81-9 | C13H10F3NO | 5g
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